Still unknown as of early November, the Omicron version has been the focus of scientists who are studying its genetics to look for possible clues about its infectivity and severity.
typeClarifies the concerns of an endless pandemic, which is always restarted by The majority version of a new candidate for the throne. Since its classification by the World Health Organization as a type of concern ( ) On November 26, 2021, nearly a hundred genetic sequences of the Omicron variant were shared by the scientific community. These sequences have been peeled off in all directions to try to predict Omicron’s behavior, its infectivity, and its severity. The first scientific publications are beginning to appear as a result of this work. team in charge and the biosecurity of Beijing Institute of Microbiology and Epidemiology a and some clues about its kinship relationship with other forms.
Omicron, the king of mutations
compared to the reference sequence of, the Omicron version has 44 replacements handjob 6 and one entry. NS S brings together 29 of these substitutions, 3 deletions and one insertion. Half of these changes concern receptor binding domain (RBD) that interacts with the ACE2 receptor. Analysis of previous variants suggests that the RBD mutation significantly modifies the behavior of the coronavirus. More precisely, nine amino acids enhance the relationship between the S protein and the ACE2 receptor, and hence its ability to infect cells. The Omicron variant has mutated on four of them: K417N, Q493R, N501Y, and Y505H. The N501Y mutation, seen in other variants, increases the affinity of the S protein for ACE2 by a factor of 9. Taken together, these mutations suggest that the Omicron variant is particularly transmissible.
Other mutations located upstream or downstream of the RBD may also participate in the epidemiological success of the Omicron variant. Revision near the cutoff site of bothProtein can strengthen S NS neutralizers. The N679K substitution, one of three identified, has never been observed anywhere else. Beyond protein S, two mutations in the nucleocaspid, the protective shell of the K genome , are also present. They are known to increase the replication of viral et, I am fine, ns , , Therefore, the Omicron variant has the potential to trigger a new global pandemic peak. write the scientists of Beijing Institute of Microbiology and Epidemiology.
a future still uncertain
Scientists suggest the Omicron version has been truncatedrather than causing severe symptoms. It is yet to be confirmed. People infected with Omicron have developed mild forms of , but they are mostly young and healthy. Origin of Omicron version remains first analysis seems rather to bring it closer to the alpha version , yet the majority when it emerged. On paper, the Omicron version has everything it takes to become a multiverse version. capacity of to slow down It remains to be determined, but primary barrier signs such as wearing a mask, ventilating enclosed spaces and washing hands are still relevant.
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