Its genome gives the first information

Still unknown as of early November, the Omicron version has been the focus of scientists who are studying its genetics to look for possible clues about its infectivity and severity.

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type omicron Clarifies the concerns of an endless pandemic, which is always restarted byEvolution The majority version of a new candidate for the throne. Since its classification by the World Health Organization as a type of concern (WHO) On November 26, 2021, nearly a hundred genetic sequences of the Omicron variant were shared by the scientific community. These sequences have been peeled off in all directions to try to predict Omicron’s behavior, its infectivity, and its severity. The first scientific publications are beginning to appear as a result of this work. team in charge pathogens and the biosecurity of Beijing Institute of Microbiology and Epidemiology a Published a detailed report on the mutation of the Omicron variant and some clues about its kinship relationship with other forms.

Omicron, the king of mutations

compared to the reference sequence of SARS-CoV-2, the Omicron version has 44 replacementsamino acidshandjob 6 deleted and one entry. NS protein S brings together 29 of these substitutions, 3 deletions and one insertion. Half of these changes concern receptor binding domain (RBD) that interacts with the ACE2 receptor. Analysis of previous variants suggests that the RBD mutation significantly modifies the behavior of the coronavirus. More precisely, nine amino acids enhance the relationship between the S protein and the ACE2 receptor, and hence its ability to infect cells. The Omicron variant has mutated on four of them: K417N, Q493R, N501Y, and Y505H. The N501Y mutation, seen in other variants, increases the affinity of the S protein for ACE2 by a factor of 9. Taken together, these mutations suggest that the Omicron variant is particularly transmissible.

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Other mutations located upstream or downstream of the RBD may also participate in the epidemiological success of the Omicron variant. Revision near the cutoff site of both sub units Protein can strengthen S Resistance NS Antibodies neutralizers. The N679K substitution, one of three identified, has never been observed anywhere else. Beyond protein S, two mutations in the nucleocaspid, the protective shell of the K genome virus, are also present. They are known to increase the replication ofarn viral et, I am fine, ns viral load, , Therefore, the Omicron variant has the potential to trigger a new global pandemic peak. write the scientists of Beijing Institute of Microbiology and Epidemiology.

a future still uncertain

Scientists suggest the Omicron version has been truncated spread fast rather than causing severe symptoms. It is yet to be confirmed. People infected with Omicron have developed mild forms of COVID-19, but they are mostly young and healthy. Origin of Omicron version remains nebulaefirst analysis phylogenetics seems rather to bring it closer to the alpha version Variant Delta, yet the majority when it emerged. On paper, the Omicron version has everything it takes to become a multiverse version. capacity of Vaccines to slow down Spreading It remains to be determined, but primary barrier signs such as wearing a mask, ventilating enclosed spaces and washing hands are still relevant.

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