- The army of immune cells that do not set the line of the epidermis in stone and are able to rearrange themselves to protect vulnerable areas.
- Immune cells show the ability to evade each other to maintain consistent protection without leaving a flaw.
As the largest organ in the human body, the skin plays an essential role. In particular, it is the body’s first defender against infectious attacks. But how does he protect the rest of the body? American researchers at the prestigious Yale University have closely examined and investigated how the epidermis, the outermost layer of skin, coordinates with immune cells against infectious attacks. His results were published in the journal on 6 May Nature Cell Biology.
Immune cells escape from each other for better protection
The army of immune cells that do not set the line of the epidermis in stone and are able to rearrange themselves to protect vulnerable areas. “It is a monitoring system with two different roles., Says Catherine Matt-Martone, the study’s first author. The skin controls these cells by arranging them according to their density, while they in turn provide dynamic coverage to prevent cracks in the skin’s defenses.“In the epidermis, there are two main types of immune system: Langerhans cells (LCs) and epidermal dendritic T cells (DETCs).
Looking closely, the researchers observed that these cells interacted with epithelial cells, the tightly packed skin cells that make up most of the epidermis. They found that the cells of the immune system maintain a minimum distance between individual cells. According to them, these immune cells show the ability to evade each other, prevent bunching, and maintain a consistent distribution. The phenomenon is similar to a property observed in neurons in which scientists have observed a tendency for single branch neurons to avoid each other.
Sale in motion
Researchers then observed the behavior of others by removing some immune cells from a region. He observed that the remaining cells are able to regenerate themselves through the skin tissue to fill in the gaps. Furthermore, they found that by destroying the R1 gene, which regulates nerve flow between immune cells, they can disrupt the normal organization of these cells. According to him, it is this process that helps maintain the distance between immune cells.
This research shows how particular types of cells can work together to play a larger role in the body. “It is interesting to see how these different types of cells coexist and interact together in a developmental context rather than in an immunological context.“, Included Matt-Martone Martone, who led the research team.
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