A chronic disease whose causes remain unknown, scleroderma is manifested by the presence of specific autoantibodies, diffuse fibrosis, vascular damage to the skin but which can spread to organs (digestive system, heart,) More common in women than men, it usually occurs between the ages of 20 and 50 but can affect children.
What are the symptoms of scleroderma?
Locally, the skin thickens and presents lesionsin plates or strips. limited systemic sclerosis ( crest) presents with a slowly progressive thickening of the skin of the face, feet, hands, forearms, feet which may be accompanied by , painful digital cysts and seizures significantly affect the quality of life of patients. Raynaud’s phenomenon (sensation of numbness, changes in the fingers and toes) of the skin) is considered a precursor of , In its diffuse form (generalized systemic sclerosis with diffuse cutaneous involvement), scleroderma can affect the joints (withdrawal) and the digestive tract. Rapidly developing, this type can present major complications in the lungs (interstitial lung disease) or kidneys (crisis.) scleroderma).
Causes and treatment of scleroderma
For reasons still unclear, endothelial cells lining the interior of small vesselsand organs are destroyed causing an inflammatory response and producing Specific. This leads to excessive formation of cell which usually participate in tissue repair with the overproduction of causes fibrosis. Therefore scleroderma is considered an autoimmune disease in which The person turns against him.
The causes of the disease are unknown. OfGenetics are discussed. Based on the detection of circulating autoantibodies. there is no cure Against scleroderma, patient management is based on treatments adapted to the affected organs. Some immunosuppressants may improve pulmonary complications.
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