Alzheimer’s: 75 Genetic Risk Factors Identified – LINFO.re

Alzheimer’s disease is the most common dementia. A study published Monday April 4 identified 75 genetic risk factors. This report is very important, as it allows for a better understanding of the pathology to better treat it.

I’Alzheimer’s is one Disease As a result of the slow degeneration of nerve cells. About 1,200,000 people are affected in France. it is undoubtedly Madness Most often, but at the moment, there is no treatment that allows a complete cure.

New genetic risk factors identified

In a study led by Inserm published in the scientific journal nature geneticsResearchers have brought together the largest group of Alzheimer’s patients to analyze their entire genomes. They looked at the genetic data of 111,326 people who were diagnosed withAlzheimer’s or their relatives are affected Diseaseand 677,663 “Control” Healthy. The study identified 75 regions of the genome associated with the disease, some of which have never been implicated in the disease before.

“Better understand cellular mechanisms and disease processes”

The study’s lead author, Jean-Charles Lambert, claimed that following this discovery, the researchers “The characterization of these regions of the genome … was identified to give meaning to them in relation to our biological and clinical knowledge”, which allows “Better understand cellular mechanisms and disease processes” included Disease, Two cerebral pathological events have already been documented: accumulation of beta-amyloid peptides and modification of tau, a protein that accumulates in neurons.

A significant advance for improving diagnostics and clinical research

Scientists have confirmed that several regions of the genome are involved in the production of amyloid peptides and the functioning of the tau protein. They were also able to develop a genetic risk score, which makes it possible to assess the risks that a person with cognitive disorders may face.Alzheimer’s Within three years of diagnosis. The study results make it possible to envisage new avenues for diagnosis and shed light on clinical research. This is a significant progress in the field.

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