Two new in vitro studies by Geneva and British researchers confirm the carcinogenic potential of aluminum salts to the human mammary gland. Especially present in deodorants and some sunscreens, these products are suspected of promoting breast cancer.
Since the late sixties, we have observed a significant increase in the incidence of breast cancer in industrialized societies. Epidemiological analyzes suggest that the risk factors identified so far – obesity, alcohol, tobacco, exposure to the hormones estrogen and progesterone – only explain a small portion of this increase.
Breast cancer develops preferably in the outer parts of the mammary gland, near the armpits, where the skin is very thin and permeable. For many years, researchers have been working on the hypothesis that aluminum salts, present in deodorants and some sunscreens in high concentrations, may be one of the reasons sought.
A team from the Center d’Onco-Hematology d’Hirslanden Clinic des Greengates in Geneva, with colleagues from the University of Oxford, United Kingdom, authors of the first study on the subject in 2016, has now analyzed several aspects of the mechanism. The action of aluminum in cell transformation in vitro.
instability of the genome
These new experiments confirm that aluminum salts are very quickly incorporated by cells, the Geneva Clinic said in a press release on Thursday. They cause significant changes in the physical structure and number of chromosomes, within 24 hours.
According to the authors, who draw parallels with asbestos and tobacco, these results indicate that aluminum directs breast cells on the path of malignant transformation by rapidly destabilizing effects of the genome.
These observations were made on large samples (approximately 300 cells per experimental condition) and by inclusion in these experiments specify the clinical, experimental model recognized in human regulatory toxicology. This work is published in the Specialized Journal International.
ATS / JFE
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